Skip to content
HARSHIL
ENTERPRISES
Stainless steel process vessels and a filtration skid in a bulk drug plant

Industry

Bulk Drugs

Bulk drug and API manufacture often includes a carbon treatment step: powdered carbon is charged into the reaction mass or solution, stirred, and filtered out, taking colour and impurities with it.

Quick answer

How is activated carbon used in bulk drug manufacturing?

In bulk drug and API manufacture, powdered activated carbon is charged into the reaction mass or solution to remove colour and impurities, then filtered out using a filter aid. Granular carbon columns are used for continuous purification of process liquids.

In the process

Where our products fit in bulk drug manufacture

The highlighted stages are where our products are used. Select a product for its technical details.

  1. 01

    Reaction

    The reaction mass is prepared.

  2. 02

    Carbon charging

    PAC is charged and stirred for decolourisation.

  3. 03

    Filtration

    Nutsche, press or sparkler, with filter aid.

  4. 04

    Solvent purification

    GAC columns for continuous purification of liquids.

  5. 05

    Isolation

    The product is crystallised and dried.

Common challenges

Common problems and how they are treated

  • Slow filtration after carbon treatment

    Filter aid as precoat and body feed.

  • Results that vary between batches

    The same approved grade, supply after supply.

  • Ash or soluble matter in product

    Washed carbon grades where purity matters.

  • Continuous liquid purification

    Granular carbon for column systems.

FAQ

Bulk Drugs: common questions

What causes slow filtration after a carbon treatment step?

Fine carbon particles can blind the filter medium. A filter aid precoat, with body feed where needed, keeps the cake porous and the filtration rate steady.

How much activated carbon is used per batch?

It depends on the product, the impurity load and the result required, and is usually established through trials. We can share grade data to support your trials.

Discuss your bulk drugs requirement

Tell us about your application and requirements. Our team will help you identify the appropriate product for your needs.

Send an Enquiry